Disseminated toxoplasmosis was diagnosed in saiga antelope (Saiga tatarica) from a Canadian zoo. Multiple foci of necrosis were found in most tissues of the animals. Toxoplasma cysts were found in association with these lesions. Toxoplasma trophozoites were recovered from mice injected with infected tissues. Subsequent to his examination of the infected saigas, enlarged lymph nodes in the author were diagnosed as toxoplasmic lymphadenitis.